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Hepatotoxicity: Serious liver injury, including irreversible drug induced hepatitis and fulminant hepatic failure sometimes fatal have been reported with use for acne treatment. Patients should be advised of the potential toxicity of this drug, particularly bone marrow suppression. Deaths have been reported due to septicemia as a result of leukopenia due to the drug. The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. Tetracycline, a related drug, is considered compatible with breastfeeding by the American Academy of Pediatrics.
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